RNA methyltransferase NSUN2-mediated m5C methylation promotes Cr(VI)-induced malignant transformation and lung cancer by accelerating metabolism reprogramming
Hexavalent chromium [Cr(VI)], one common environmental contaminant, has long been recognized as a carcinogen associated Fishing Gear with lung cancer, but roles and mechanisms of Cr(VI)-induced epigenetic dysregulations in carcinogenesis remain to be investigated.In this study, we identified that RNA m5C methyltransferase NSUN2 was significantly up